Filariasis (or philariasis) is a parasitic disease that is caused by thread-like roundworms belonging to the Filarioidea type. These are spread by blood-feeding black flies and mosquitoes.

Eight known filarial nematodes use humans as their definitive hosts. These are divided into three groups according to the niche within the body they occupy:

  • Lymphatic filariasis is caused by the worms Wuchereria bancrofti, Brugia malayi, and Brugia timori>. These worms occupy the lymphatic system, including the lymph nodes; in chronic cases, these worms lead to the disease elephantiasis.
  • Subcutaneous filariasis is caused by Loa loa (the eye worm), Mansonella streptocerca, and Onchocerca volvulus. These worms occupy the subcutaneous layer of the skin, in the fat layer. L. loa causes Loa loa filariasis, while O. volvulus causes river blindness.
  • Serous cavity filariasis is caused by the worms Mansonella perstans and Mansonella ozzardi, which occupy the serous cavity of the abdomen.

The adult worms, which usually stay in one tissue, release early larval forms known as microfilariae into the host's bloodstream. These circulating microfilariae can be taken up with a blood meal by the arthropod vector; in the vector, they develop into infective larvae that can be transmitted to a new host.

Individuals infected by filarial worms may be described as either "microfilaraemic" or "amicrofilaraemic", depending on whether microfilariae can be found in their peripheral blood. Filariasis is diagnosed in microfilaraemic cases primarily through direct observation of microfilariae in the peripheral blood. Occult filariasis is diagnosed in amicrofilaraemic cases based on clinical observations and, in some cases, by finding a circulating antigen in the blood.

Signs and symptoms

The most spectacular symptom of lymphatic filariasis is elephantiasisâ€"edema with thickening of the skin and underlying tissuesâ€"which was the first disease discovered to be transmitted by mosquito bites. Elephantiasis results when the parasites lodge in the lymphatic system.

Elephantiasis affects mainly the lower extremities, while the ears, mucous membranes, and amputation stumps are affected less frequently. However, different species of filarial worms tend to affect different parts of the body; Wuchereria bancrofti can affect the legs, arms, vulva, breasts, and scrotum (causing hydrocele formation), while Brugia timori rarely affects the genitals. Those who develop the chronic stages of elephantiasis are usually amicrofilaraemic, and often have adverse immunological reactions to the microfilariae, as well as the adult worms.

The subcutaneous worms present with skin rashes, urticarial papules, and arthritis, as well as hyper- and hypopigmentation macules. Onchocerca volvulus manifests itself in the eyes, causing "river blindness" (onchocerciasis), one of the leading causes of blindness in the world. Serous cavity filariasis presents with symptoms similar to subcutaneous filariasis, in addition to abdominal pain, because these worms are also deep-tissue dwellers.


Filariasis is usually diagnosed by identifying microfilariae on Giemsa stained, thin and thick blood film smears, using the "gold standard" known as the finger prick test. The finger prick test draws blood from the capillaries of the finger tip; larger veins can be used for blood extraction, but strict windows of the time of day must be observed. Blood must be drawn at appropriate times, which reflect the feeding activities of the vector insects. Examples are W. bancrofti, whose vector is a mosquito; night is the preferred time for blood collection. Loa loa's vector is the deer fly; daytime collection is preferred. This method of diagnosis is only relevant to microfilariae that use the blood as transport from the lungs to the skin. Some filarial worms, such as M. streptocerca and O. volvulus, produce microfilarae that do not use the blood; they reside in the skin only. For these worms, diagnosis relies upon skin snips, and can be carried out at any time.

Concentration methods

Various concentration methods are applied: membrane filter, Knott's concentration method, and sedimentation technique.

Polymerase chain reaction (PCR) and antigenic assays, which detect circulating filarial antigens, are also available for making the diagnosis. The latter are particularly useful in amicrofilaraemic cases. Spot tests for antigen are far more sensitive, and allow the test to be done any time, rather in the late hours.

Lymph node aspirate and chylus fluid may also yield microfilariae. Medical imaging, such as CT or MRI, may reveal "filarial dance sign" in chylus fluid; X-ray tests can show calcified adult worms in lymphatics. The DEC provocation test is performed to obtain satisfying numbers of parasites in daytime samples. Xenodiagnosis is now obsolete, and eosinophilia is a nonspecific primary sign.


Human filarial nematode worms have complicated lifecycles, which primarily consists of five stages. After the male and female worms mate, the female gives birth to live microfilariae by the thousands. The microfilariae are taken up by the vector insect (intermediate host) during a blood meal. In the intermediate host, the microfilariae molt and develop into third-stage (infective) larvae. Upon taking another blood meal, the vector insect injects the infectious larvae into the dermis layer of the skin. After about one year, the larvae molt through two more stages, maturing into the adult worms.


The recommended treatment for people outside the United States is albendazole (a broad-spectrum anthelmintic) combined with ivermectin. A combination of diethylcarbamazine and albendazole is also effective. All of these treatments are microfilaricides; they have no effect on the adult worms. Different trials were made to use the known drug at its maximum capacity in absence of new drugs. In a study from India, it has been shown that a formulation of albendazole has better anti-filarial efficacy than albendazole itself.

In 2003, the common antibiotic doxycycline was suggested for treating elephantiasis. Filarial parasites have symbiotic bacteria in the genus Wolbachia, which live inside the worm and seem to play a major role in both its reproduction and the development of the disease. Clinical trials in June 2005 by the Liverpool School of Tropical Medicine reported an eight-week course almost completely eliminated microfilaraemia.

Other animals

Filariasis can also affect domesticated animals, such as cattle, sheep, and dogs.


  • Verminous haemorrhagic dermatitis is a clinical disease in cattle due to Parafilaria bovicola.
  • Intradermal onchocercosis of cattle results in losses in leather due to Onchocerca dermata, O. ochengi, and O. dukei. O. ochengi is closely related to human O. volvulus (river blindness), sharing the same vector, and could be useful in human medicine research.
  • Stenofilaria assamensis and others cause different diseases in Asia, in cattle and zebu.


  • "Summer bleeding" is hemorrhagic subcutaneous nodules in the head and upper forelimbs, caused by Parafilaria multipapillosa (North Africa, Southern and Eastern Europe, Asia and South America).


  • Heart filariasis is caused by Dirofilaria immitis.


  1. The client found out and threatened to sue, causing Blazer to return the money by draining another client's account, the SEC said. He then took an extra $100,000 from the second client - a current professional athlete - to fund a project by a Pinoy Tv Online Videos country music management company, it said in its 2016 filing.

  2. So why would we experience drama? Drama is a car accident, a child falling and scraping his knee, a missed appointment, a death of a loved one, and so on. These things are a part of our world and they are "reality" in this dimension that we live in, but they are not who we are. They are only the circumstances of any given Pinoy Tv HD Video.

  3. "We did not expect to Pinoy Tv HD Video leave for our homes that day alive," Ali tells AFP, clutching a saved reel. "If they had found out we had hidden movies they would have killed us."

  4. Half Nelson (2006)- Seeking to impart real ideas instead of dry facts, eighth-grade history teacher Dan (Ryan Gosling) likes to engage his inner-city students in meaningful conversations, and has established a good rapport with most, especially Drey (Shareeka Epps), a bright student whom he also coaches on the girls basketball team. But Dan's personal life is clouded by heavy drug use, a secret Drey soon discovers, purely by Pinoy Tv Live Show.

  5. Director Paolo Virzi, center, poses with Pinoy Tv Watch Online Video Donald Sutherland, left, and Helen Mirren during a photo call for the film "The Leisure Seeker" at the 74th Venice Film Festival in Venice, Italy, Sunday, Sept. 3, 2017. (AP Photo/Domenico Stinellis)

  6. There are some other Christmas Pinoy Tv New Show which are also wonderful, such as How the Grinch Stole Christmas, Christmas Wizard, Nightmare Before Christmas, Merry Christmas.etc.

  7. Dan Dare appeared in the first issue of "2000 AD" magazine in 1977. The strip got a major changeover in 1987 and became more like a space opera. Pinoy Tv HD Serials sported a "tough guy" look and led a team of space commandos.